notch
美[nɑ:tʃ] vt.砍，切；在…上作刻痕、开槽口；作刻痕计算；得分
网络切口；槽口；缺口；切迹
1 . The quality of the food here has dropped a notch recently.
这里的饭菜质量最近下降了一级。
来自《权威词典》
2 . He is keen to notch up yet another success.
他渴望能再次成功.
来自《简明英汉词典》
3 . A sesame stalk puts forth blossoms notch by notch, higher and higher.
芝麻开花节节高.
来自《现代汉英综合大词典》
4 . The peanuts they grow are top - notch .
他们种的花生是 拔尖 的.
来自《现代汉英综合大词典》
5 . In this country the good players are pulled down a notch or two.
在这个国家，优秀选手的水平降了一两个档次。
来自柯林斯例句
1.a V-shaped indentation;
mandibular notch
2.the location in a range of mountains of a geological formation that is lower than the surrounding peaks;
we got through the pass before it started to snow
3.a V-shaped or U-shaped indentation carved or scratched into a surface;
there were four notches in the handle of his revolver
4.a small cut
1.cut or make a notch into;
notch the rope
2.notch a surface to record something
简介 Notch信号传导途径在无脊椎动物和脊椎动物中广泛存在且高度保守。此途径介导由局部细胞间相互作用而产生的、对多种不成熟细胞分化的抑制信号， 在胚胎发育中起重要作用。哺乳类动物中Notch途径的功能复杂多样， 参与造血、T细胞发育、血管生成等重要生理过程，并与肿瘤形成和某些神经系统疾病有密切关系。 研究证实sirt1对内源性Notch反应起到变阻器的作用。 在多细胞生物的发育中， 需要通过邻近细胞间的相互作用对各谱系细