1.direct or control; projects, businesses, etc.;
She is running a relief operation in the Sudan
2.perform as expected when applied;
The washing machine won't go unless it's plugged in
3.handle and cause to function;
do not operate machinery after imbibing alcohol
4.perform a movement in military or naval tactics in order to secure an advantage in attack or defense
5.happen;
What is going on in the minds of the people?
6.keep engaged;
engaged the gears
7.perform surgery on;
The doctors operated ont he patient but failed to save his life